Article
The DNA damage response at eroded telomeres and tethering to the nuclear pore complex.
Nature cell biology - 1 Aug 2009
Khadaroo Basheer, Teixeira M Teresa, Luciano Pierre, Eckert-Boulet Nadine, Germann Susanne M, Simon Marie Noelle, Gallina Irene, Abdallah Pauline, Gilson Eric, Géli Vincent, Lisby Michael
Abstract excerpt
The ends of linear eukaryotic chromosomes are protected by telomeres, which serve to ensure proper chromosome replication and to prevent spurious recombination at chromosome ends. In this study, we show by single cell analysis that in the absence of telomerase, a single short telomere is sufficient to induce the recruitment of checkpoint and recombination proteins. Notably, a DNA damage response at eroded...
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