Article
Influence of sex and genetic variability on expression of X-linked genes in human monocytes.
Genomics - 1 Nov 2011
Castagné Raphaële, Zeller Tanja, Rotival Maxime, Szymczak Silke, Truong Vinh, Schillert Arne, Trégouët David-Alexandre, Münzel Thomas, Ziegler Andreas, Cambien François, Blankenberg Stefan, Tiret Laurence
Abstract excerpt
In humans, the fraction of X-linked genes with higher expression in females has been estimated to be 5% from microarray studies, a proportion lower than the 25% of genes thought to escape X inactivation. We analyzed 715 X-linked transcripts in circulating monocytes from 1,467 subjects and found an excess of female-biased transcripts on the X compared to autosomes (9.4% vs 5.5%, p<2×10(-5)). Among the genes not...
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