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Article

Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.

Nature genetics - 25 Mar 2012

Fairfax Benjamin P, Makino Seiko, Radhakrishnan Jayachandran, Plant Katharine, Leslie Stephen, Dilthey Alexander, Ellis Peter, Langford Cordelia, Vannberg Fredrik O, Knight Julian C

Abstract excerpt

Trans-acting genetic variants have a substantial, albeit poorly characterized, role in the heritable determination of gene expression. Using paired purified primary monocytes and B cells, we identify new predominantly cell type-specific cis and trans expression quantitative trait loci (eQTLs), including multi-locus trans associations to LYZ and KLF4 in monocytes and B cells, respectively. Additionally, we observe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22446964
DOI: 10.1038/ng.2205
PMCID: PMC3437404

Genes

AOAH
ARHGAP24
KLF4
LYZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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