Article
The impact of sex on gene expression across human tissues.
Science (New York, N.Y.) - 11 Sept 2020
Oliva Meritxell, Muñoz-Aguirre Manuel, Kim-Hellmuth Sarah, Wucher Valentin, Gewirtz Ariel D H, Cotter Daniel J, Parsana Princy, Kasela Silva, Balliu Brunilda, Viñuela Ana, Castel Stephane E, Mohammadi Pejman, Aguet François, Zou Yuxin, Khramtsova Ekaterina A, Skol Andrew D, Garrido-Martín Diego, Reverter Ferran, Brown Andrew, Evans Patrick, Gamazon Eric R, Payne Anthony, Bonazzola Rodrigo, Barbeira Alvaro N, Hamel Andrew R, Martinez-Perez Angel, Soria José Manuel, Pierce Brandon L, Stephens Matthew, Eskin Eleazar, Dermitzakis Emmanouil T, Segrè Ayellet V, Im Hae Kyung, Engelhardt Barbara E, Ardlie Kristin G, Montgomery Stephen B, Battle Alexis J, Lappalainen Tuuli, Guigó Roderic, Stranger Barbara E
Abstract excerpt
Many complex human phenotypes exhibit sex-differentiated characteristics. However, the molecular mechanisms underlying these differences remain largely unknown. We generated a catalog of sex differences in gene expression and in the genetic regulation of gene expression across 44 human tissue sources surveyed by the Genotype-Tissue Expression project (GTEx, v8 release). We demonstrate that sex influences gene...
Topics
- Chromosomes, Human, X
- Disease
- Epigenesis, Genetic
- Female
- Gene Expression
- Gene Expression Regulation