Article
Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression.
PloS one - 1 Jan 2012
Almlöf Jonas Carlsson, Lundmark Per, Lundmark Anders, Ge Bing, Maouche Seraya, Göring Harald H H, Liljedahl Ulrika, Enström Camilla, Brocheton Jessy, Proust Carole, Godefroy Tiphaine, Sambrook Jennifer G, Jolley Jennifer, Crisp-Hihn Abigail, Foad Nicola, Lloyd-Jones Heather, Stephens Jonathan, Gwilliam Rhian, Rice Catherine M, Hengstenberg Christian, Samani Nilesh J, Erdmann Jeanette, Schunkert Heribert, Pastinen Tomi, Deloukas Panos, Goodall Alison H, Ouwehand Willem H, Cambien François, Syvänen Ann-Christine
Abstract excerpt
A large number of genome-wide association studies have been performed during the past five years to identify associations between SNPs and human complex diseases and traits. The assignment of a functional role for the identified disease-associated SNP is not straight-forward. Genome-wide expression quantitative trait locus (eQTL) analysis is frequently used as the initial step to define a function while...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.