Article
Functional characterization of the cleavage specificity of the sapovirus chymotrypsin-like protease.
Journal of virology - 1 Aug 2008
Robel Ivonne, Gebhardt Julia, Mesters Jeroen R, Gorbalenya Alexander, Coutard Bruno, Canard Bruno, Hilgenfeld Rolf, Rohayem Jacques
Abstract excerpt
Sapovirus is a positive-stranded RNA virus with a translational strategy based on processing of a polyprotein precursor by a chymotrypsin-like protease. So far, the molecular mechanisms regulating cleavage specificity of the viral protease are poorly understood. In this study, the catalytic activ...
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