Identification of the active-site residues of the 3C proteinase of foot-and-mouth disease virus.

doi:10.1006/viro.1995.0030

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Article

Identification of the active-site residues of the 3C proteinase of foot-and-mouth disease virus.

Virology - 10 Nov 1995

Grubman M J, Zellner M, Bablanian G, Mason P W, Piccone M E

Abstract excerpt

To identify the active-site residues of the 3C proteinase of foot-and-mouth disease virus (FMDV), we introduced mutations into the 3C coding region and examined the activity of mutant enzymes on various substrates. Based on alignment of FMDV 3C with other picornavirus 3C proteinases and with the...

Topics

3C Viral Proteases
Animals
Aphthovirus
Binding Sites
Cysteine Endopeptidases
Mutagenesis, Site-Directed
Mutation
Transfection
Viral Proteins
Virus Replication

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