Article
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.
The FEBS journal - 1 Sept 2011
Chen Zhe-Sheng, Tiwari Amit K
Abstract excerpt
The ATP-binding cassette (ABC) transporters are a superfamily of membrane proteins that are best known for their ability to transport a wide variety of exogenous and endogenous substances across membranes against a concentration gradient via ATP hydrolysis. There are seven subfamilies of human ABC transporters, one of the largest being the 'C' subfamily (gene symbol ABCC). Nine ABCC subfamily members, the...
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