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Article

Multidrug resistance‐associated proteins and implications in drug development

29 Jun 2009

Abstract excerpt

1. The multidrug resistance-associated proteins (MRPs) belong to the ATP-binding cassette superfamily (ABCC family) of transporters that are expressed differentially in the liver, kidney, intestine and blood-brain barrier. There are nine human MRPs that transport a structurally diverse array of endo- and xenobiotics as well as their conjugates. 2. Multidrug resistance-associated protein 1 can be distinguished...

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PMID: 19566819
DOI: 10.1111/j.1440-1681.2009.05252.x

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