Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.

International journal of toxicology - 1 Jan 2000

Choudhuri Supratim, Klaassen Curtis D

Abstract excerpt

The ATP-binding cassette (ABC) transporters constitute a large family of membrane proteins, which transport a variety of compounds through the membrane against a concentration gradient at the cost of ATP hydrolysis. Substrates of the ABC transporters include lipids, bile acids, xenobiotics, and peptides for antigen presentation. As they transport exogenous and endogenous compounds, they reduce the body load of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP-Binding Cassette Transporters

Share to Biodegradation, Environmental

Share to Gene Expression Regulation

Share to Genes, MDR

Share to Neoplasm Proteins

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 16815813
DOI: 10.1080/10915810600746023

Genes

ABCB1
ABCG2
ABCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.PMID 16815813Read ↗

ABC Multidrug Transporters: Structure, Function and Role in ChemoresistanceSemantic proximity Read ↗

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application.Semantic proximity Read ↗

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.Semantic proximity Read ↗

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.Semantic proximity Read ↗

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)Semantic proximity Read ↗

Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response.Semantic proximity Read ↗

Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense SystemSemantic proximity Read ↗

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2Semantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

Pharmacogenomic importance of ABCG2.Semantic proximity Read ↗

MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions.Semantic proximity Read ↗

Intracellular trafficking of MDR transporters and relevance of SNPs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.