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Article

Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.

Handbook of experimental pharmacology - 1 Jan 2011

Keppler Dietrich

Abstract excerpt

The nine multidrug resistance proteins (MRPs) represent the major part of the 12 members of the MRP/CFTR subfamily belonging to the 48 human ATP-binding cassette (ABC) transporters. Cloning, functional characterization, and cellular localization of most MRP subfamily members have identified them as ATP-dependent efflux pumps with a broad substrate specificity for the transport of endogenous and xenobiotic anionic...

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Source

Identifiers

PMID: 21103974
DOI: 10.1007/978-3-642-14541-4_8

Genes

ABCC6
ABCC8
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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