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Article

Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters

1 Aug 2005

Abstract excerpt

Genetic variations in drug metabolizing enzymes and targets are established determinants of adverse drug reactions and interactions, but less is known about the role of genetic polymorphisms in membrane transport proteins. MRP1 (ABCC1) is one of 13 polytopic membrane proteins that comprise the 'C' subfamily of the ATP-binding cassette (ABC) superfamily of transport proteins. MRP1 and related ABCC family members,...

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PMID: 16006996
DOI: 10.1097/01.fpc.0000167333.38528.ec

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