Article
MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jul 2008
Toyoda Y, Hagiya Y, Adachi T, Hoshijima K, Kuo M T, Ishikawa T
Abstract excerpt
1. The adenosine triphosphate (ATP) binding cassette (ABC) transporters form one of the largest protein families encoded in the human genome, and more than 48 genes encoding human ABC transporters have been identified and sequenced. It has been reported that mutations of ABC protein genes are causative in several genetic disorders in humans. 2. Many human ABC transporters are involved in membrane transport of...
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