Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2002

Gerk Phillip M, Vore Mary

Abstract excerpt

The multidrug resistance protein 2 (MRP2; ABCC2) is an ATP-binding cassette transporter accepting a diverse range of substrates, including glutathione, glucuronide, and sulfate conjugates of many endo- and xenobiotics. MRP2 generally performs excretory or protective roles, and it is expressed on the apical domain of hepatocytes, enterocytes of the proximal small intestine, and proximal renal tubular cells, as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Multiple
Share to Exons
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

Share to Multidrug Resistance-Associated Protein 2

Share to Multidrug Resistance-Associated Proteins

Share to Phylogeny

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 12130697
DOI: 10.1124/jpet.102.035014

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition.PMID 12130697Read ↗

Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition.Semantic proximity Read ↗

Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition.Semantic proximity Read ↗

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application.Semantic proximity Read ↗

Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs.Semantic proximity Read ↗

Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.Semantic proximity Read ↗

MRP subfamily transporters and resistance to anticancer agents.Semantic proximity Read ↗

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.Semantic proximity Read ↗

The apical conjugate efflux pump ABCC2 (MRP2).Semantic proximity Read ↗

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.Semantic proximity Read ↗

Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.Semantic proximity Read ↗

Multidrug resistance‐associated proteins and implications in drug developmentSemantic proximity Read ↗

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.