Article
Regulation of Rad51 function by phosphorylation.
EMBO reports - 8 Jul 2011
Flott Sonja, Kwon Youngho, Pigli Ying Zhang, Rice Phoebe A, Sung Patrick, Jackson Stephen P
Abstract excerpt
Rad51 is a key enzyme involved in DNA double-strand break repair by homologous recombination. Here, we show that in response to DNA damage, budding yeast Rad51 is phosphorylated on Ser 192 in a manner that is primarily mediated by the DNA-damage-responsive protein kinase Mec1. We show that mutating Rad51 Ser 192 to Ala or Glu confers hypersensitivity to DNA damage and homologous-recombination defects....
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