Article
Multiple start codons and phosphorylation result in discrete Rad52 protein species.
Nucleic acids research - 1 Jan 2006
Antúnez de Mayolo Adriana, Lisby Michael, Erdeniz Naz, Thybo Tanja, Mortensen Uffe H, Rothstein Rodney
Abstract excerpt
The sequence of the Saccharomyces cerevisiae RAD52 gene contains five potential translation start sites and protein-blot analysis typically detects multiple Rad52 species with different electrophoretic mobilities. Here we define the gene products encoded by RAD52. We show that the multiple Rad52 protein species are due to promiscuous choice of start codons as well as post-translational modification. Specifically,...
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