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Article

Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.

Molecular cell - 13 Nov 2009

Niu Hengyao, Wan Lihong, Busygina Valeria, Kwon YoungHo, Allen Jasmina A, Li Xue, Kunz Ryan C, Kubota Kazuishi, Wang Beatrice, Sung Patrick, Shokat Kevan M, Gygi Steven P, Hollingsworth Nancy M

Abstract excerpt

A preference for homologs over sister chromatids in homologous recombination is a fundamental difference in meiotic versus mitotic cells. In budding yeast, the bias for interhomolog recombination in meiosis requires the Dmc1 recombinase and the meiosis-specific kinase Mek1, which suppresses engagement of sister chromatids by the mitotic recombinase Rad51. Here, a combination of proteomic, biochemical, and genetic...

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Identifiers

PMID: 19917248
DOI: 10.1016/j.molcel.2009.09.029
PMCID: PMC2788773

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Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.PMID 19917248Read ↗

Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.Semantic proximity Read ↗

Mek1 kinase governs outcomes of meiotic recombination and the checkpoint response.Semantic proximity Read ↗

The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.Semantic proximity Read ↗

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.Semantic proximity Read ↗

Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.Semantic proximity Read ↗

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complexSemantic proximity Read ↗

A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint.Semantic proximity Read ↗

Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.Semantic proximity Read ↗

A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.Semantic proximity Read ↗

Pachytene exit controlled by reversal of Mek1-dependent phosphorylation.Semantic proximity Read ↗

Evidence that MEK1 positively promotes interhomologue double-strand break repair.Semantic proximity Read ↗

Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).Semantic proximity Read ↗

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