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Article

Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair.

Genes & development - 1 Nov 1994

Donovan J W, Milne G T, Weaver D T

Abstract excerpt

Rad51 is essential for efficient repair of DNA double-strand breaks (DSBs) and recombination in Saccharomyces cerevisiae. Here, we examine Rad51 protein-protein interactions and their biological significance. GAL4 two-hybrid fusion analysis demonstrated that the amino-terminal region of Rad51 mediates both a strong Rad51:Rad51 self-association and a Rad51:Rad52 interaction. Several Rad51 variants were...

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Source

Identifiers

PMID: 7958917
DOI: 10.1101/gad.8.21.2552

Genes

RAD51
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair.PMID 7958917Read ↗

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Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants.Semantic proximity Read ↗

Molecular dissection of interactions between Rad51 and members of the recombination-repair group.Semantic proximity Read ↗

Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapySemantic proximity Read ↗

RAD-ical New Insights into RAD51 RegulationSemantic proximity Read ↗

Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52.Semantic proximity Read ↗

RAD-ical New Insights into RAD51 RegulationSemantic proximity Read ↗

The Role of the Rad55-Rad57 Complex in DNA Repair.Semantic proximity Read ↗

Complex Formation by the Human Rad51B and Rad51C DNA Repair Proteins and Their Activities in VitroSemantic proximity Read ↗

Interaction with Rad51 is indispensable for recombination mediator function of Rad52.Semantic proximity Read ↗

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