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Article

FHA domain-mediated DNA checkpoint regulation of Rad53.

Cell cycle (Georgetown, Tex.) - 1 Jan 2000

Schwartz Marc F, Lee Soo-Jung, Duong Jimmy K, Eminaga Seda, Stern David F

Abstract excerpt

Saccharomyces cerevisiae Rad53 is a protein kinase central to the DNA damage and DNA replication checkpoint signaling pathways. In addition to its catalytic domain, Rad53 contains two forkhead homology-associated (FHA) domains (FHA1 and FHA2), which are phosphopeptide binding domains. The Rad53 FHA domains are proposed to mediate the interaction of Rad53 with both upstream and downstream branches of the DNA...

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PMID: 12851493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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