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Article

Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism.

Molecular and cellular biology - 1 Apr 2004

Naiki Takahiro, Wakayama Tatsushi, Nakada Daisuke, Matsumoto Kunihiro, Sugimoto Katsunori

Abstract excerpt

Rad9 is required for the activation of DNA damage checkpoint pathways in budding yeast. Rad9 is phosphorylated after DNA damage in a Mec1- and Tel1-dependent manner and subsequently interacts with Rad53. This Rad9-Rad53 interaction has been suggested to trigger the activation and phosphorylation...

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Identifiers

PMID: 15060150
DOI: 10.1128/MCB.24.8.3277-3285.2004
PMCID: PMC381673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15060150-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism.PMID 15060150Read ↗

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint.Semantic proximity Read ↗

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.Semantic proximity Read ↗

Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling.Semantic proximity Read ↗

A domain of Rad9 specifically required for activation of Chk1 in budding yeast.Semantic proximity Read ↗

Activation of the budding yeast securin Pds1 but not Rad53 correlates with double-strand break-associated G2/M cell cycle arrest in a mec1 hypomorphic mutant.Semantic proximity Read ↗

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.Semantic proximity Read ↗

A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage.Semantic proximity Read ↗

Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.Semantic proximity Read ↗

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.Semantic proximity Read ↗

Protein kinase C controls activation of the DNA integrity checkpoint.Semantic proximity Read ↗

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