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Article

Topoisomerase IIalpha controls the decatenation checkpoint.

Nature cell biology - 1 Feb 2009

Luo Kuntian, Yuan Jian, Chen Junjie, Lou Zhenkun

Abstract excerpt

Topoisomerase II (Topo II) is required to separate intertwined sister chromatids before chromosome segregation can occur in mitosis. However, it remains to be resolved whether Topo II has any role in checkpoint control. Here we report that when phosphorylated, Ser 1524 of Topo IIalpha acts as a binding site for the BRCT domain of MDC1 (mediator of DNA damage checkpoint protein-1), thereby recruiting MDC1 to...

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Share to Antigens, Neoplasm
Share to Chromatin
Share to DNA Topoisomerases, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Genes, cdc

Share to Genomic Instability

Share to RNA, Small Interfering

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Source

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Identifiers

PMID: 19098900
DOI: 10.1038/ncb1828
PMCID: PMC2712943

Genes

MDC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Topoisomerase IIalpha controls the decatenation checkpoint.PMID 19098900Read ↗

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A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint.Semantic proximity Read ↗

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DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisSemantic proximity Read ↗

Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.Semantic proximity Read ↗

A mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin.Semantic proximity Read ↗

The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.Semantic proximity Read ↗

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.Semantic proximity Read ↗

CIP2A coordinates phosphosignaling, mitosis, and the DNA damage responseSemantic proximity Read ↗

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell SurvivalSemantic proximity Read ↗

Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read ↗

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