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Article

Evidence of meiotic crossover control in Saccharomyces cerevisiae through Mec1-mediated phosphorylation of replication protein A.

Genetics - 1 Jan 2006

Bartrand Amy J, Iyasu Dagmawi, Marinco Suzanne M, Brush George S

Abstract excerpt

Replication protein A (RPA) is the major single-stranded DNA-binding protein in eukaryotes, essential for DNA replication, repair, and recombination. During mitosis and meiosis in budding yeast, RPA becomes phosphorylated in reactions that require the Mec1 protein kinase, a central checkpoint regulator and homolog of human ATR. Through mass spectrometry and site-directed mutagenesis, we have now identified a...

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Source

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Identifiers

PMID: 16118184
DOI: 10.1534/genetics.105.047845
PMCID: PMC1456154

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence of meiotic crossover control in Saccharomyces cerevisiae through Mec1-mediated phosphorylation of replication protein A.PMID 16118184Read ↗

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.Semantic proximity Read ↗

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Proteins in the nutrient-sensing and DNA damage checkpoint pathways cooperate to restrain mitotic progression following DNA damage.Semantic proximity Read ↗

Replication protein A (AtRPA1a) is required for class I crossover formation but is dispensable for meiotic DNA break repair.Semantic proximity Read ↗

Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responsesSemantic proximity Read ↗

In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling.Semantic proximity Read ↗

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The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

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Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.Semantic proximity Read ↗

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