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Article

The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.

Cell cycle (Georgetown, Tex.) - 1 Dec 2010

Tougan Takahiro, Kasama Takashi, Ohtaka Ayami, Okuzaki Daisuke, Saito Takamune T, Russell Paul, Nojima Hiroshi

Abstract excerpt

Mek1 is a Chk2/Rad53/Cds1-related protein kinase that is required for proper meiotic progression of Schizosaccharomyces pombe. However, the molecular mechanisms of Mek1 regulation and Mek1 phosphorylation targets are unclear. Here, we report that Mek1 is phosphorylated at serine-12 (S12), S14 and threonine-15 (T15) by Rad3 (ATR) and/or Tel1 (ATM) kinases that are activated by meiotic programmed double-strand...

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Identifiers

PMID: 21084840
DOI: 10.4161/cc.9.23.14050
PMCID: PMC3048037

Genes

ATM
ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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