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Article

A Rad53 kinase-dependent surveillance mechanism that regulates histone protein levels in S. cerevisiae.

Cell - 26 Nov 2003

Gunjan Akash, Verreault Alain

Abstract excerpt

Rad53 and Mec1 are protein kinases required for DNA replication and recovery from DNA damage in Saccharomyces cerevisiae. Here, we show that rad53, but not mec1 mutants, are extremely sensitive to histone overexpression, as Rad53 is required for degradation of excess histones. Consequently, excess histones accumulate in rad53 mutants, resulting in slow growth, DNA damage sensitivity, and chromosome loss...

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Identifiers

PMID: 14651846
DOI: 10.1016/s0092-8674(03)00896-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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