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Article

Molecular cloning of the human DNA excision repair gene ERCC-6.

Molecular and cellular biology - 1 Nov 1990

Troelstra C, Odijk H, de Wit J, Westerveld A, Thompson L H, Bootsma D, Hoeijmakers J H

Abstract excerpt

The UV-sensitive, nucleotide excision repair-deficient Chinese hamster mutant cell line UV61 was used to identify and clone a correcting human gene, ERCC-6. UV61, belonging to rodent complementation group 6, is only moderately UV sensitive in comparison with mutant lines in groups 1 to 5. It harbors a deficiency in the repair of UV-induced cyclobutane pyrimidine dimers but permits apparently normal repair of...

Topics

Animals
Blotting, Southern
Cell Line
Cell Survival
Cloning, Molecular
DNA Repair
DNA Transposable Elements
DNA, Neoplasm
Genes
HeLa Cells
Humans
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Transfection

Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 2172786
DOI: 10.1128/mcb.10.11.5806-5813.1990
PMCID: PMC361360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2172786-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Molecular cloning of the human DNA excision repair gene ERCC-6.PMID 2172786Read ↗

Molecular cloning and biological characterization of the human excision repair gene ERCC-3.Semantic proximity Read ↗

Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21.Semantic proximity Read ↗

UV-sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterparts.Semantic proximity Read ↗

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Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.Semantic proximity Read ↗

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Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.Semantic proximity Read ↗

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