Article
Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.
The EMBO journal - 1 Sept 1993
van Vuuren A J, Appeldoorn E, Odijk H, Yasui A, Jaspers N G, Bootsma D, Hoeijmakers J H
Abstract excerpt
Nucleotide excision repair (NER), one of the major cellular DNA repair systems, removes a wide range of lesions in a multi-enzyme reaction. In man, a NER defect due to a mutation in one of at least 11 distinct genes, can give rise to the inherited repair disorders xeroderma pigmentosum (XP), Cock...
Topics
- Acetoxyacetylaminofluorene
- Animals
- Antibodies
- CHO Cells
- Cell-Free System
- Cockayne Syndrome
- Cricetinae
- DNA Damage
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins
- Endonucleases
- Fungal Proteins
- Genetic Complementation Test
- Humans