Article
The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61.
Nucleic acids research - 1 Sept 1996
Orren D K, Dianov G L, Bohr V A
Abstract excerpt
The human CSB gene, mutated in Cockayne's syndrome group B (partially defective in both repair and transcription) was previously cloned by virtue of its ability to correct the moderate UV sensitivity of the CHO mutant UV61. To determine whether the defect in UV61 is the hamster equivalent of Cock...
Topics
- Animals
- CHO Cells
- Cell Survival
- Cell-Free System
- Cockayne Syndrome
- Cricetinae
- DNA Helicases
- DNA Polymerase II
- DNA Repair
- DNA Repair Enzymes
- Dose-Response Relationship, Radiation
- Genes, myc
- Genetic Complementation Test
- Humans
- Mutation
- Poly-ADP-Ribose Binding Proteins
- Pyrimidine Dimers
- Transcription, Genetic