Article
Use of gene targeting to study recombination in mammalian cell DNA repair mutants.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2006
Nairn Rodney S, Adair Gerald M
Abstract excerpt
Gene targeting by homologous recombination in mammalian cells is an important tool for generating genetically modified mice used for modeling human diseases. Gene targeting approaches are also useful for studying the mechanisms of homologous recombination. We have developed gene targeting methods that we have specifically used to investigate the mechanisms of recombination in cultured mammalian cells. In this...
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