Article
The human DNA repair gene, ERCC2 (XPD), corrects ultraviolet hypersensitivity and ultraviolet hypermutability of a shuttle vector replicated in xeroderma pigmentosum group D cells.
Cancer research - 15 Jul 1994
Gözükara E M, Parris C N, Weber C A, Salazar E P, Seidman M M, Watkins J F, Prakash L, Kraemer K H
Abstract excerpt
To determine the contribution of a human DNA repair gene, ERCC2 (XPD), to mutagenesis in human cells, two ERCC2 (XPD)-transformed xeroderma pigmentosum complementation group D (XPD) cell lines with increased UV survival compared to XP6BE(SV40), the original XPD line, were studied: D6BE-ER2-2 with...
Topics
- Adult
- Base Sequence
- Cell Line
- Cell Survival
- Chloramphenicol O-Acetyltransferase
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Female
- Genetic Vectors
- Humans
- Molecular Sequence Data
- Mutation
- Plasmids
- Proteins