Article
Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.
Molecular and cellular biology - 1 Dec 1990
Thompson L H, Brookman K W, Jones N J, Allen S A, Carrano A V
Abstract excerpt
We describe the cloning and function of the human XRCC1 gene, which is the first mammalian gene isolated that affects cellular sensitivity to ionizing radiation. The CHO mutant EM9 has 10-fold-higher sensitivity to ethyl methanesulfonate, 1.8-fold-higher sensitivity to ionizing radiation, a reduc...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Cell Survival
- Cloning, Molecular
- Cosmids
- DNA
- DNA Repair
- Gene Library
- Genes
- Humans
- Kinetics
- Molecular Sequence Data
- Mutation
- Plasmids
- Restriction Mapping
- Sister Chromatid Exchange