Cyclobutane-pyrimidine dimer excision in UV-sensitive CHO mutants and the effect of the human ERCC2 repair gene.

doi:10.1016/0921-8777(90)90069-h

Back to search

Article

Cyclobutane-pyrimidine dimer excision in UV-sensitive CHO mutants and the effect of the human ERCC2 repair gene.

Mutation research - 1 May 1990

Regan J D, Thompson L H, Carrier W L, Weber C A, Francis A A, Zdzienicka M Z

Abstract excerpt

Using a radiochromatographic assay, we have examined cis-syn cyclobutane-pyrimidine dimer removal after ultraviolet irradiation in cell lines representative of the first 6 complementation groups of Chinese hamster ovary DNA nucleotide excision repair mutants. AA8, the CHO cell line from which the...

Topics

Animals
Cell Line
Cricetinae
Cricetulus
DNA Repair
DNA, Bacterial
Genes
Humans
Mutation
Pyrimidine Dimers
Transformation, Genetic
Ultraviolet Rays

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.