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Article

The genetic defect in the Chinese hamster ovary cell mutant UV61 permits moderate selective repair of cyclobutane pyrimidine dimers in an expressed gene.

Mutation research - 1 Sept 1991

Lommel L, Hanawalt P C

Abstract excerpt

We examined removal of cyclobutane pyrimidine dimers (CPDs) from the dihydrofolate reductase (DHFR) gene in ultraviolet-irradiated Chinese hamster ovary (CHO) UV61 and UV5 cells. The sensitivity of UV61 cells to UV-irradiation is intermediate between that of the parental CHO cells and that of mutants such as UV5 that are highly defective in excision repair. UV61 cells have been characterized as having normal...

Topics

Animals
CHO Cells
Chromosome Mapping
Cricetinae
Cyclobutanes
DNA Repair
Gene Expression
Mutation
Plasmids
Pyrimidine Dimers
RNA Probes
Tetrahydrofolate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1922150
DOI: 10.1016/0921-8777(91)90052-q

Genes

DHFR
CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1922150-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The genetic defect in the Chinese hamster ovary cell mutant UV61 permits moderate selective repair of cyclobutane pyrimidine dimers in an expressed gene.PMID 1922150Read ↗

The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61.Semantic proximity Read ↗

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