Molecular cloning and biological characterization of the human excision repair gene ERCC-3.

doi:10.1128/mcb.10.6.2570-2581.1990

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Article

Molecular cloning and biological characterization of the human excision repair gene ERCC-3.

Molecular and cellular biology - 1 Jun 1990

Weeda G, van Ham R C, Masurel R, Westerveld A, Odijk H, de Wit J, Bootsma D, van der Eb A J, Hoeijmakers J H

Abstract excerpt

In this report we present the cloning, partial characterization, and preliminary studies of the biological activity of a human gene, designated ERCC-3, involved in early steps of the nucleotide excision repair pathway. The gene was cloned after genomic DNA transfection of human (HeLa) chromosomal DNA together with dominant marker pSV3gptH to the UV-sensitive, incision-defective Chinese hamster ovary (CHO) mutant...

Topics

Alkylating Agents
Animals
Blotting, Southern
Cell Line
Cloning, Molecular
DNA
DNA Repair
DNA Replication
Genes
Genomic Library
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Methyl Methanesulfonate

Mitomycin

Mitomycins

Mutation

Nucleic Acid Hybridization

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 2111438
DOI: 10.1128/mcb.10.6.2570-2581.1990
PMCID: PMC360615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2111438-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Molecular cloning and biological characterization of the human excision repair gene ERCC-3.PMID 2111438Read ↗

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