Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Class-switch recombination: after the dawn of AID.

Current opinion in immunology - 1 Apr 2003

Kenter Amy L

Abstract excerpt

Isotype class switching is central to the humoral immune response. The discovery that mutations in the activation-induced deaminase (AID) gene inhibit class-switch recombination, somatic hypermutation and gene conversion is a major step forward in defining the underlying mechanisms of these gene modification events. The propensity of mutations to occur at dC/dG nucleotides during somatic hypermutation and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to Cytidine Deaminase
Share to AICDA (Activation-Induced Cytidine Deaminase)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Gene Conversion

Share to Genes, Immunoglobulin

Share to Immunoglobulin Class Switching

Share to Models, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12633669
DOI: 10.1016/s0952-7915(03)00018-9
PMCID: PMC4975044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Class-switch recombination: after the dawn of AID.PMID 12633669Read ↗

Mini‐review Activation‐induced cytidine deaminase: a dual role in class‐switch recombination and somatic hypermutationSemantic proximity Read ↗

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationSemantic proximity Read ↗

AID in Antibody Diversification: There and Back Again.Semantic proximity Read ↗

Targeting of AID-mediated sequence diversification to immunoglobulin genes.Semantic proximity Read ↗

DNA deamination in immunitySemantic proximity Read ↗

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Semantic proximity Read ↗

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.Semantic proximity Read ↗

Biological function of activation-induced cytidine deaminase (AID)Semantic proximity Read ↗

AID Biology: A pathological and clinical perspectiveSemantic proximity Read ↗

AID-initiated purposeful mutations in immunoglobulin genes.Semantic proximity Read ↗

Oncogenic events triggered by AID, the adverse effect of antibody diversificationSemantic proximity Read ↗

Haploinsufficiency of Activation-Induced Deaminase for Antibody Diversification and Chromosome Translocations both In Vitro and In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.