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Article

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

Molecular cell - 1 Aug 2003

Barreto Vasco, Reina-San-Martin Bernardo, Ramiro Almudena R, McBride Kevin M, Nussenzweig Michel C

Abstract excerpt

Class-switch recombination (CSR), somatic hypermutation (SHM), and antibody gene conversion are distinct DNA modification reactions, but all are initiated by activation-induced cytidine deaminase (AID), an enzyme that deaminates cytidine residues in single-stranded DNA. Here we describe a mutant form of AID that catalyzes SHM and gene conversion but not CSR. When expressed in E. coli, AID(delta189-198) is more...

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Identifiers

PMID: 14536088
DOI: 10.1016/s1097-2765(03)00309-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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