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Article

Nrd1 interacts with the nuclear exosome for 3' processing of RNA polymerase II transcripts.

Molecular cell - 20 Jan 2006

Vasiljeva Lidia, Buratowski Stephen

Abstract excerpt

The exosome complex is involved in multiple RNA processing and degradation pathways. How exosome is recruited to particular RNA substrates and then chooses between RNA processing and degradation modes remains unclear. We find that the RNA binding protein Nrd1, complexed with its partners Nab3, Sen1, and cap binding complex, physically interacts with the nuclear form of exosome. Nrd1 stimulates the RNA degradation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16427013
DOI: 10.1016/j.molcel.2005.11.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nrd1 interacts with the nuclear exosome for 3' processing of RNA polymerase II transcripts.PMID 16427013Read ↗

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The nuclear exosome contributes to autogenous control of NAB2 mRNA levels.Semantic proximity Read ↗

Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance.Semantic proximity Read ↗

H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.Semantic proximity Read ↗

The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome.Semantic proximity Read ↗

The Ess1 prolyl isomerase is required for transcription termination of small noncoding RNAs via the Nrd1 pathway.Semantic proximity Read ↗

The EDC4-XRN1 axis controls P-body dynamics to link mRNA decapping with decaySemantic proximity Read ↗

A nuclear RNA degradation code for eukaryotic transcriptome surveillanceSemantic proximity Read ↗

The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay.Semantic proximity Read ↗

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.Semantic proximity Read ↗

The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome.Semantic proximity Read ↗

Termination of cryptic unstable transcripts is directed by yeast RNA-binding proteins Nrd1 and Nab3.Semantic proximity Read ↗

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