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Article

The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition.

Nucleic acids research - 29 Sept 2017

Franco-Echevarría Elsa, González-Polo Noelia, Zorrilla Silvia, Martínez-Lumbreras Santiago, Santiveri Clara M, Campos-Olivas Ramón, Sánchez Mar, Calvo Olga, González Beatriz, Pérez-Cañadillas José Manuel

Abstract excerpt

Transcription termination of non-coding RNAs is regulated in yeast by a complex of three RNA binding proteins: Nrd1, Nab3 and Sen1. Nrd1 is central in this process by interacting with Rbp1 of RNA polymerase II, Trf4 of TRAMP and GUAA/G terminator sequences. We lack structural data for the last of these binding events. We determined the structures of Nrd1 RNA binding domain and its complexes with three...

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PMID: 28973465
DOI: 10.1093/nar/gkx685
PMCID: PMC5737872

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