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Article

RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene, DEF1, Involves Sen1-Dependent and Polyadenylation Site-Dependent Termination.

G3 (Bethesda, Md.) - 31 May 2018

Whalen Courtney, Tuohy Christine, Tallo Thomas, Kaufman James W, Moore Claire, Kuehner Jason N

Abstract excerpt

Termination of RNA Polymerase II (Pol II) activity serves a vital cellular role by separating ubiquitous transcription units and influencing RNA fate and function. In the yeast Saccharomyces cerevisiae, Pol II termination is carried out by cleavage and polyadenylation factor (CPF-CF) and Nrd1-Nab3-Sen1 (NNS) complexes, which operate primarily at mRNA and non-coding RNA genes, respectively. Premature Pol II...

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PMID: 29686108
DOI: 10.1534/g3.118.200072
PMCID: PMC5982831

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