Article
The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome.
The Journal of biological chemistry - 20 Dec 2013
Heo Dong-hyuk, Yoo Inhea, Kong Jiwon, Lidschreiber Michael, Mayer Andreas, Choi Byung-Yi, Hahn Yoonsoo, Cramer Patrick, Buratowski Stephen, Kim Minkyu
Abstract excerpt
The RNA polymerase II (RNApII) C-terminal domain (CTD)-interacting domain (CID) proteins are involved in two distinct RNApII termination pathways and recognize different phosphorylated forms of CTD. To investigate the role of differential CTD-CID interactions in the choice of termination pathway, we altered the CTD-binding specificity of Nrd1 by domain swapping. Nrd1 with the CID from Rtt103 (Nrd1(CID(Rtt103)))...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.