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Article

A genetic screen for terminator function in yeast identifies a role for a new functional domain in termination factor Nab3.

Nucleic acids research - 1 Aug 2012

Loya Travis J, O'Rourke Thomas W, Reines Daniel

Abstract excerpt

The yeast IMD2 gene encodes an enzyme involved in GTP synthesis. Its expression is controlled by guanine nucleotides through a set of alternate start sites and an intervening transcriptional terminator. In the off state, transcription results in a short non-coding RNA that starts upstream of the gene. Transcription terminates via the Nrd1-Nab3-Sen1 complex and is degraded by the nuclear exosome. Using a sensitive...

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Identifiers

PMID: 22564898
DOI: 10.1093/nar/gks377
PMCID: PMC3424548

Genes

PCF11
SSU72

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A genetic screen for terminator function in yeast identifies a role for a new functional domain in termination factor Nab3.PMID 22564898Read ↗

The RNA binding protein Nab2 genetically interacts with multiple RNA exosome cofactors to regulate target RNAsSemantic proximity Read ↗

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