Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma.

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Article

Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma.

Molecular biology & medicine - 1 Jun 1990

Dejean A, de Thé H

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is etiologically related to human hepatocellular carcinoma (HCC). Most HCCs contain integrated HBV DNA in the liver cellular DNA, suggesting that the integration may be involved in carcinogenesis. From a comparison of a single HBV integration site present in a hepatoma with the corresponding unoccupied site in the non-tumourous tissue of the same liver, we have shown that...

Topics

Amino Acid Sequence
Base Sequence
Carcinoma, Hepatocellular
Carrier Proteins
Cell Transformation, Neoplastic
DNA
DNA, Neoplasm
DNA, Viral
Exons
Gene Expression Regulation, Neoplastic
Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis B

Hepatitis B virus

Humans

Liver Neoplasms

Molecular Sequence Data

Mutation

Organ Specificity

Source

Open in PubMed

Identifiers

PMID: 2170809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2170809-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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