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Article

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator.

Nature - 1 Feb 1990

Kekulé A S, Lauer U, Meyer M, Caselmann W H, Hofschneider P H, Koshy R

Abstract excerpt

Hepatitis B virus (HBV) is regarded as the main aetiologic factor in the development of human hepatocellular carcinoma (HCC), one of the most frequent fatal malignancies worldwide. Detection of integrated HBV sequences in the cellular DNA of almost all HCCs studied, and the recent finding that the integrated HBV open reading frame (orf) X encodes a transactivating activity, supports the notion that integrated HBV...

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PMID: 2153938
DOI: 10.1038/343457a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator.PMID 2153938Read ↗

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Hepatitis B virus enhancer 1 activates preS1 and preS2 promoters of integrated HBV DNA impairing HBsAg secretionSemantic proximity Read ↗

The TATA-less promoter of hepatitis B virus S gene contains a TBP binding site and an active initiator.Semantic proximity Read ↗

Hepatoma-derived integrated HBV DNA causes multi-stage transformation in vitro.Semantic proximity Read ↗

Temporal aspects of major viral transcript expression in Hep G2 cells transfected with cloned hepatitis B virus DNA: with emphasis on the X transcript.Semantic proximity Read ↗

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The genome of hepatitis B virus contains a second enhancer: cooperation of two elements within this enhancer is required for its functionSemantic proximity Read ↗

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