Article
The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator.
Nature - 1 Feb 1990
Kekulé A S, Lauer U, Meyer M, Caselmann W H, Hofschneider P H, Koshy R
Abstract excerpt
Hepatitis B virus (HBV) is regarded as the main aetiologic factor in the development of human hepatocellular carcinoma (HCC), one of the most frequent fatal malignancies worldwide. Detection of integrated HBV sequences in the cellular DNA of almost all HCCs studied, and the recent finding that th...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Hepatocellular
- Chloramphenicol O-Acetyltransferase
- Cloning, Molecular
- DNA, Viral
- Hepatitis B virus
- Humans
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Trans-Activators
- Transcription, Genetic
- Transcriptional Activation
- Transfection
- Tumor Cells, Cultured