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Article

cis-Activation of the Human Telomerase Gene (hTERT) by the Hepatitis B Virus Genome

1 Aug 2001

Abstract excerpt

Telomerase catalyzes the elongation of telomeric repeat DNA to maintain telomere length and structure (1). Although telomerase is a complex composed of a catalytic subunit (hTERT) and an RNA component (hTER), it is the expression of hTERT (2,3) that is the major determinant of telomerase activity in human cells (1,4). Maintaining telomere length by telomerase is associated with human cell immortalization and...

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PMID: 11481390
DOI: 10.1093/jnci/93.15.1171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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cis-Activation of the Human Telomerase Gene (hTERT) by the Hepatitis B Virus GenomePMID 11481390Read ↗

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The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator.Semantic proximity Read ↗

The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes.Semantic proximity Read ↗

Hepatoma-derived integrated HBV DNA causes multi-stage transformation in vitro.Semantic proximity Read ↗

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Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus statusSemantic proximity Read ↗

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