Article
Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging.
Oncogene - 27 Sept 2001
Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Bréchot C, Paterlini-Bréchot P
Abstract excerpt
Proviral tagging has been used in animals as a powerful tool for cancer genetics. We show that a similar approach is possible in patients with hepatocellular carcinoma (HCC) infected by Hepatitis B Virus (HBV), a human pararetrovirus which may act by insertional mutagenesis. In this work, the HBV genome is used as a probe to identify cancer-related genes. By using HBV-Alu-PCR, we obtained 21 HBV/cellular DNA...
Topics
- Base Sequence
- Blotting, Northern
- Carcinoma, Hepatocellular
- Cell Division
- DNA
- DNA, Complementary
- Exons
- Hepatitis B virus
- Humans
- Introns
- Models, Genetic