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Article

Mechanism of kinase activation in the receptor for colony-stimulating factor 1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990

Lee A W, Nienhuis A W

Abstract excerpt

Receptor tyrosine kinases remain dormant until activated by ligand binding to the extracellular domain. Two mechanisms have been proposed for kinase activation: (i) ligand binding to the external domain of a receptor monomer may induce a conformational change that is transmitted across the cell membrane (intramolecular model) or (ii) the ligand may facilitate oligomerization, thereby allowing interactions between...

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Identifiers

PMID: 2169623
DOI: 10.1073/pnas.87.18.7270
PMCID: PMC54725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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