Mechanism of kinase activation in the receptor for colony-stimulating factor 1.

doi:10.1073/pnas.87.18.7270

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Article

Mechanism of kinase activation in the receptor for colony-stimulating factor 1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990

Lee A W, Nienhuis A W

Abstract excerpt

Receptor tyrosine kinases remain dormant until activated by ligand binding to the extracellular domain. Two mechanisms have been proposed for kinase activation: (i) ligand binding to the external domain of a receptor monomer may induce a conformational change that is transmitted across the cell m...

Topics

Amino Acid Sequence
Animals
Cell Division
Cell Line
Colony-Stimulating Factors
DNA Replication
Enzyme Activation
Gene Expression
Gene Library
Humans
Kinetics
Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Receptor, Macrophage Colony-Stimulating Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 2169623
DOI: 10.1073/pnas.87.18.7270
PMCID: PMC54725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2169623-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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