Article
Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.
Blood - 22 Apr 2010
Perugini Michelle, Brown Anna L, Salerno Diana G, Booker Grant W, Stojkoski Cvetan, Hercus Timothy R, Lopez Angel F, Hibbs Margaret L, Gonda Thomas J, D'Andrea Richard J
Abstract excerpt
Granulocyte/macrophage colony-stimulating factor promotes growth, survival, differentiation, and activation of normal myeloid cells and plays an important role in myeloid leukemias. The GM-CSF receptor (GMR) shares a signaling subunit, beta(c), with interleukin-3 and interleukin-5 receptors and has recently been shown to induce activation of Janus kinase 2 (JAK2) and downstream signaling via formation of a unique...
Topics
- Animals
- Blotting, Western
- Cell Line
- Enzyme Activation
- Flow Cytometry
- Immunoprecipitation
- Leukemia, Myeloid, Acute
- Mice
- Microscopy, Fluorescence
- Mutation
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
- Signal Transduction