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Article

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.

Blood - 22 Apr 2010

Perugini Michelle, Brown Anna L, Salerno Diana G, Booker Grant W, Stojkoski Cvetan, Hercus Timothy R, Lopez Angel F, Hibbs Margaret L, Gonda Thomas J, D'Andrea Richard J

Abstract excerpt

Granulocyte/macrophage colony-stimulating factor promotes growth, survival, differentiation, and activation of normal myeloid cells and plays an important role in myeloid leukemias. The GM-CSF receptor (GMR) shares a signaling subunit, beta(c), with interleukin-3 and interleukin-5 receptors and has recently been shown to induce activation of Janus kinase 2 (JAK2) and downstream signaling via formation of a unique...

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Source

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Identifiers

PMID: 20173116
DOI: 10.1182/blood-2009-08-235846
PMCID: PMC2858480

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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