Article
Effects of transmembrane and juxtamembrane domains on proliferative ability of TSLP receptor.
Molecular immunology - 1 Mar 2010
Zhong Jun, Liu Xuedong, Pandey Akhilesh
Abstract excerpt
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that requires a heterodimeric receptor complex composed of the interleukin-7 receptor alpha chain and the TSLP receptor, which is related to the common gamma chain. TSLP has been shown to play an important role in the development of allergic inflammation, such as asthma and atopic dermatitis. Chimeric receptors composed of the cytoplasmic region of the...
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