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Article

Extracellular domain of the transforming growth factor-beta receptor negatively regulates ligand-independent receptor activation.

The Journal of biological chemistry - 8 Oct 1999

Zhu H J, Sizeland A M

Abstract excerpt

We have previously proposed that transforming growth factor (TGF)-beta receptor activation occurs via a relative rotation between the receptors. This model suggests that in the absence of the ligand the receptor extracellular domain negatively regulates the activation of the receptor complex. To investigate this proposition, four TGF-beta type I and II receptor extracellular/transmembrane-cytoplasmic and...

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PMID: 10506179
DOI: 10.1074/jbc.274.41.29220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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