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Article

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.

Oncogene - 11 Apr 2002

Kiyoi Hitoshi, Ohno Ryuzo, Ueda Ryuzo, Saito Hidehiko, Naoe Tomoki

Abstract excerpt

Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosine residues, while the mechanism remains unclear. In this study, we elucidated the role of the JM...

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Source

Identifiers

PMID: 11971190
DOI: 10.1038/sj.onc.1205332

Genes

FLT3
IL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.PMID 11971190Read ↗

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.Semantic proximity Read ↗

Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation.Semantic proximity Read ↗

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product.Semantic proximity Read ↗

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