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Article

A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?

Biochemistry - 1 Apr 1997

Groenen L C, Walker F, Burgess A W, Treutlein H R

Abstract excerpt

The binding of epidermal growth factor (EGF) to its receptor leads to receptor dimerization, which activates the intracellular kinase domain. Homology models of the inactive and active forms of the EGF-receptor kinase domains have been derived, and these models suggest that the active form can be stabilized by the interaction of helix C and the surrounding area in one receptor monomer with one of two possible...

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Source

Identifiers

PMID: 9092812
DOI: 10.1021/bi9614141

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?PMID 9092812Read ↗

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.Semantic proximity Read ↗

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